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Randomized Trial of Weekly Sulfadoxine/Pyrimethamine vs. Daily Low-Dose Trimethoprim-Sulfamethoxazole for the Prophylaxis of Pneumocystis carinii Pneumonia After Liver Transplantation

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Randomized Trial of Weekly Sulfadoxine/Pyrimethamine vs. Daily Low-Dose Trimethoprim-Sulfamethoxazole for the Prophylaxis of Pneumocystis carinii Pneumonia After Liver Transplantation

Auteurs : J. Torre-Cisneros [Espagne] ; M. De La Mata [Espagne] ; J. C. Pozo [Espagne] ; P. Serrano [Espagne] ; J. Brice O [Espagne] ; G. Sol Rzano [Espagne] ; G. Mi O [Espagne] ; C. Pera [Espagne] ; P. Sánchez-Guijo [Espagne]

Source :

Clinical Infectious Diseases [ 1058-4838 ] ; 1999.

RBID : ISTEX:E1D75285888F94A0CEF3F945BF2B0202B63118F0

Abstract

We conducted a prospective, randomized clinical trial among liver transplant patients to assess the efficacy and safety of weekly sulfadoxine/pyrimethamine compared with daily trimethoprimsulfamethoxazole in the prevention of Pneumocystis carinii pneumonia. The studied drugs were given during 6 months after transplantation. One hundred twenty patients were included. None of the 60 patients receiving weekly sulfadoxine/pyrimethamine developed Pneumocystis carinii pneumonia, whereas two cases (3%) developed among the 60 patients who received trimethoprimsulfamethoxazole. For both patients, the studied medication had been discontinued several weeks earlier because of adverse effects. No differences were observed in the incidence of adverse effects. We conclude that weekly sulfadoxine/pyrimethamine is as effective and safe as is daily trimethoprim-sulfamethoxazole in the prophylaxis of Pneumocystis carinii pneumonia after liver transplantation.

Url:

https://api.istex.fr/ark:/67375/HXZ-FC6C0WF4-D/fulltext.pdf

DOI: 10.1086/520432

Affiliations:

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Le document en format XML

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<front><div type="abstract">We conducted a prospective, randomized clinical trial among liver transplant patients to assess the efficacy and safety of weekly sulfadoxine/pyrimethamine compared with daily trimethoprimsulfamethoxazole in the prevention of Pneumocystis carinii pneumonia. The studied drugs were given during 6 months after transplantation. One hundred twenty patients were included. None of the 60 patients receiving weekly sulfadoxine/pyrimethamine developed Pneumocystis carinii pneumonia, whereas two cases (3%) developed among the 60 patients who received trimethoprimsulfamethoxazole. For both patients, the studied medication had been discontinued several weeks earlier because of adverse effects. No differences were observed in the incidence of adverse effects. We conclude that weekly sulfadoxine/pyrimethamine is as effective and safe as is daily trimethoprim-sulfamethoxazole in the prophylaxis of Pneumocystis carinii pneumonia after liver transplantation.</div>
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Randomized Trial of Weekly Sulfadoxine/Pyrimethamine vs. Daily Low-Dose Trimethoprim-Sulfamethoxazole for the Prophylaxis of Pneumocystis carinii Pneumonia After Liver Transplantation

Randomized Trial of Weekly Sulfadoxine/Pyrimethamine vs. Daily Low-Dose Trimethoprim-Sulfamethoxazole for the Prophylaxis of Pneumocystis carinii Pneumonia After Liver Transplantation

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Abstract

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